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Flea and Tick Prevention for Dogs

Wags Advance®

The affordable, dependable, topical solution to kill and prevent ticks, mosquitoes, lice and all three life-cycle stages of biting fleas.
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Wags Advance® kills and repels fleas, ticks, and lice on dogs. This topical treatment is vet-formulated, safe, and effective at eliminating all stages of the flea life cycle.

How to use

Remove the tube from the package. Hold it vertically and trim the end with scissors. Part your dog’s fur and apply the treatment starting at the base of their neck. Apply equally in 3-4 spots along their spine ending at the top of their tail. Throw the applicator away.

Tips for use

  • Match the box with your dog’s name and photo

  • Make sure your dog’s weight is within the range on the product label

  • Avoid bathing or swimming at least 48 hours before and after treatment

  • Apply every 30 days to prevent re-infestation

Important information

This product is for animal use only. Keep out of reach of children. Apply treatment every 30 days as soon as your box arrives for the best results.

*This product is not manufactured or distributed by Elanco, the maker of K9 Advantix® II. K9 Advantix® II is a registered trademark of Elanco.

Safe & Effective Treatment for Dogs

Vet-quality, wallet-friendly

Proudly made in the USA, Wags Advance® for Dogs is vet-quality and regulated and approved by the EPA.

“PetFriendly’s flea and tick topical solution for dogs compares to the leading brands and is the best choice when protecting your pet. Wags Advance® for Dogs is affordable for pet parents without losing the quality that vets recommend.”

Dr. Olaf Hansen, DVM

PetFriendly Vet Team

Custom Flea Medicine for Dogs

The perfect fit for every dog

Your dog is the star of their own treatment box. The best flea treatment for dogs is human-proof with friendly instructions so you can forget about remembering.

Human-Proof Flea & Tick Treatment

No confusion

Match the name and photo with the corresponding pet to ensure they’re getting the right treatment every time. Wags Advance® for Dogs is perfect for dogs 7 weeks of age or older and at least 4 pounds.

How to Apply Topical Treatment

Confirm your dog’s weight matches their treatment. Remove the applicator, hold it vertically, and cut the tip.
Part your dog’s fur and apply the entire treatment in 3-4 spots from the base of their neck to the top of their tail.
Do not bathe your dog for at least 48 hours. Once the treatment has dried, immediately resume snuggling.
Your monthly delivery is perfectly timed to keep your pet protected from fleas and ticks.
Full Instructions

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Frequently Asked Questions

About Wags Advance® for Dogs

Want to learn more? Explore our commonly asked questions about our topical flea and tick treatment for dogs.

What’s in it?

Wags Advance® topical flea treatment for dogs is produced in the USA and contains the same active ingredients found in Bayer’s K9 Advantix® II for Dogs:

Wags Advance® for Dogs is EPA-approved safe and effective. The primary active ingredient is featured in big-name brands, and PetFriendly products are customized and conveniently delivered straight to your door at an affordable price.

What does it do?

Wags Advance® for Dogs topical flea treatment:

  • Rapidly and critically kills and repels ticks, mosquitoes, lice, and all three life stages of biting fleas (eggs, larvae, and adult fleas).

  • Is effective at killing fleas within 12 hours and continues to prevent reinfestations for up to a month. This includes all types of fleas like cat fleas and dog fleas.

  • Will kill ticks at all life stages that may transmit Lyme disease. Wags Advance® covers the American dog tick, Black-legged deer tick, Brown dog tick, and Lone Star tick.

  • May reduce the incidence of flea allergy dermatitis (FAD), a hypersensitivity skin disorder induced by the feeding activity of fleas.

Helps prevent dangerous diseases from flea and tick bites such as Lyme disease. It does not cover mosquitoes, so your dog will need heartworm prevention for full coverage.

How do I apply?

Applying Wags Advance® topical flea treatment for dogs is simple:

  • Find your dog and make sure the star of the box matches your pet.

  • Prepare the applicator by holding it upright and cutting the tip with scissors.

  • Part your dog’s fur and hold the applicator tip to your dog’s skin starting at the base of the neck.

  • Gently squeeze the applicator to empty the contents equally in 3-4 spots from their neck to the base of their tail.

  • Discard the applicator in the trash and resume snuggling once the solution is dry.*

*Wait at least 24-48 hours before bathing or submerging in water. If you have any additional questions read our full instructions.

How long does it last?

A single dose of Wags Advance® for Dogs is effective for 30 days. For best protection, we recommend treating the moment your box arrives. We deliver your pet's topical flea treatment every month on application day.

Does it cause any side effects?

While typically very rare, flea treatments (topicals, chewable, prescription oral flea/tick treatment, wearable treatments like flea collars) can cause mild side effects.

The most common health-related symptoms include:

  • Hair loss

  • Skin irritation

  • Gastrointestinal problems

  • Lethargy

If these symptoms do not go away, contact your vet right away. You can also reach our emergency medical line at (888) 738-3911 — they are available 24/7.

How is it dosed?

One dose of Wags Advance® flea meds for dogs is EPA-approved safe and effective for dogs weighing at least 4 pounds. Each topical flea treatment is dosed according to your pet's current weight:

  • Wags Advance® for Small Dogs: 4 to 10 pounds

  • Wags Advance® for Medium Dogs: 11 to 20 pounds

  • Wags Advance® for Large Dogs: 21 to 55 pounds

  • Wags Advance® for Extra Large Dogs: 56 pounds or more

All of our products are formulated by vets and dosed to your pet's unique weight and health needs.

Does it require a prescription?

Nope! Wags Advance® for Dogs is delivered straight to your door without a prescription, vet visit, or trip to the store. But, we recommend checking with your vet if you are switching from another over-the-counter flea and tick prevention for the health of your pet.

How old does my pup need to be?

Your puppy should be at least 7 weeks old and at least 4 pounds before using Wags Advance® flea treatments. We recommend checking with your veterinarian before starting treatment for puppies and dogs. Learn more about when to start flea and tick treatment on puppies.

Is it waterproof? Can I bathe my dog?

Wags Advance® for Dogs is waterproof but requires the natural oils in your dog's skin and fur to properly distribute the active ingredients, such as imidacloprid, effectively.

Avoid bathing your dog or allowing them to go swimming for at least 48 hours before and after applying topical treatments. If you bathe your dog often or want to kill adult fleas and remove flea dirt we recommend using mild pet shampoo.

Can I use this product on my pregnant, nursing, or breeding dog?

Our Wags Advance® for Dogs topical flea & tick protection has not been tested on breeding, nursing, or pregnant dogs. We always recommend you discuss applying any product to your dog in these conditions with your veterinarian. Feel free to contact our veterinarian team at help@petfriendlybox.com before you reach out to your vet.

Is it safe for cats?

No! Wags Advance® for Dogs can be fatal for cats. Keep your cats away from treated dogs for at least 24 hours after treatment. Multi-pet owners — Paws Plus® for Cats flea, tick, and lice protection is for you.

Does it work against ear mites?

This product does not work against heartworms, ear mites, roundworms, hookworms, or tapeworms. You will need a heartworm preventative in addition to this product. But, this product prevents and kills fleas, ticks, mosquitoes, and chewing lice.

Can I use other flea & tick treatments in combination with others?

We recommend you pick one flea medicine brand and stick to that treatment exclusively:

  • If you are using another topical brand (like Frontline®), we recommend bathing your pet in degreasing dish soap and applying our topical flea and tick prevention 24-48 hours after.

  • If you are using a flea collar or tick collar, we recommend bathing your pet in Dawn dish soap and applying our topical medication 24-48 hours after.

  • If you are treating with oral medications (like Bravecto®), we recommend waiting 30 days after treating your dog before applying our topical solution.

  • If you use or have already used shampoo, but want to switch to Wags Advance® for Dogs, contact our veterinarian team at help@petfriendlybox.com.

Flea and tick meds are not created equally. Chat with your vet about the dog flea meds for your pup.

Why don't you offer oral flea treatment for dogs?

We currently offer topical treatments for dogs because they are the most convenient and effective way to kill and prevent pests and parasites. We started with a topical rather than an oral treatment (like Sentinel® or Bravecto®) because:

  • Oral treatments reside in your dog’s bloodstream.
    This requires insects to bite your dog to be effective. That bite can lead to other health problems for your animal, such as Flea Allergy Dermatitis (FAD).

  • Oral treatments typically require a prescription from a vet.
    Most oral treatments require a prescription from your veterinarian. Wags Advance® for Dogs is an over-the-counter topical treatment that gets delivered to your door just a few days after signing up.

  • Oral flea and tick treatments are often more expensive.
    Wags Advance® for Dogs costs 20-40% less than the big brands (like Frontline®). Plus, you'll save on the time and cost of a vet visit. Choosing the right medication for your pet may depend on the price, types of protection available, and lifestyle. No matter what you choose, consult with your veterinarian about potential risks.

I still see fleas and ticks, what gives?

Gaining control of an infestation can take anywhere from 30 days to several months. Parasites can wreak havoc on your pets and in your home.

  • For your pets: The best way to control parasites is through consistent protection. This will help you prevent and kill pests and prevent diseases and re-infestations. Be sure to follow the instructions provided.

  • For your home: Treat your home with a household spray that has IGRs. Best-in-class sprays cover a combination of fleas, ticks, lice, and other pests. We have one available to add to your box that will take care of the insects and parasites in your home.

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